South Dakota DEA registration and controlled substance licensing

Facts

DEA listing

DEA lists South Dakota under: Second CS License Requirement

Note

DEA's page titles this column 'Second CS License Requirement', which DEA's page presents as a state controlled substance license in addition to the medical license. Confirm the exact requirement with the South Dakota licensing board before prescribing.

DEA: Medical State Licensure and/or Controlled Substance Licensure

Moving to or adding South Dakota

• Get the South Dakota license first.
• Then apply for or update the DEA registration for South Dakota. Per the DEA Registration Q&A, a separate DEA registration is needed in each state where you practice and dispense controlled substances.
• DEA registration page

NPs and PAs

DEA treats NPs and PAs as mid-level practitioners. Authority comes from state law, so check the South Dakota board.

Neighbors

2 of the 6 bordering states are listed with a second-CS-license flag: Iowa, Wyoming.

• Iowa — second-CS-license flag.
• Minnesota — one-license flag.
• Montana — one-license flag.
• Nebraska — one-license flag.
• North Dakota — one-license flag.
• Wyoming — second-CS-license flag.

Count named qualifying land/river neighbors; exclude water-only and corner-only contacts. Neighbor status grants no practice authority.

In this state, in context

BLS OEWS May 2025 annual mean employee wages — nurse practitioners: $125,160; physician assistants: $131,910. These are employee wage estimates, not total compensation or contract rates.

South Dakota nurse practitioners pay · South Dakota physician assistants pay · South Dakota nurse anesthetists pay

Decision checklist for South Dakota

• Use the South Dakota practice address, not only an employer’s name, when reviewing the registration question.
• Confirm the rule for each principal dispensing place at one general physical location in 21 CFR 1301.12.
• Check state authority with the relevant board before relying on DEA registration.

The DEA Registration Q&A separately addresses different-state practices; confirm individual state authority.

Find your state board (FSMB directory)

Sources

• DEA: Medical State Licensure and/or Controlled Substance Licensure
• DEA Diversion Control Division: Registration Q&A
• 21 CFR 1301.12 (Cornell LII)
• DEA: Registration

General information, not legal or insurance advice. Confirm details with the state board, DEA, or the carrier.