South Carolina DEA registration and controlled substance licensing

Facts

DEA listing

DEA lists South Carolina under: Second CS License Requirement

Note

DEA's page titles this column 'Second CS License Requirement', which DEA's page presents as a state controlled substance license in addition to the medical license. Confirm the exact requirement with the South Carolina licensing board before prescribing.

DEA: Medical State Licensure and/or Controlled Substance Licensure

Moving to or adding South Carolina

• Get the South Carolina license first.
• Then apply for or update the DEA registration for South Carolina. Per the DEA Registration Q&A, a separate DEA registration is needed in each state where you practice and dispense controlled substances.
• DEA registration page

NPs and PAs

DEA treats NPs and PAs as mid-level practitioners. Authority comes from state law, so check the South Carolina board.

In this state, in context

BLS OEWS May 2025 annual mean employee wages — physicians, all other: $286,140; nurse practitioners: $124,170; physician assistants: $120,720. “Physicians, all other” is a broad category, not all physicians or a specialty average. These are employee wage estimates, not total compensation or contract rates.

South Carolina physicians, all other pay · South Carolina nurse practitioners pay · South Carolina physician assistants pay · South Carolina nurse anesthetists pay

Decision checklist for South Carolina

• Map the actual South Carolina dispensing locations before asking about registration.
• Check the separate-location rule in 21 CFR 1301.12 rather than assuming a registration follows you everywhere.
• Ask the state board to confirm authority to dispense; federal registration does not replace that review.

The DEA Registration Q&A separately addresses different-state practices; confirm individual state authority.

Find your state board (FSMB directory)

Neighbors

0 of the 2 bordering states are listed with a second-CS-license flag: none.

• Georgia — one-license flag.
• North Carolina — one-license flag.

Count named qualifying land/river neighbors; exclude water-only and corner-only contacts. Neighbor status grants no practice authority.

Sources

• DEA: Medical State Licensure and/or Controlled Substance Licensure
• DEA Diversion Control Division: Registration Q&A
• 21 CFR 1301.12 (Cornell LII)
• DEA: Registration

General information, not legal or insurance advice. Confirm details with the state board, DEA, or the carrier.