Illinois DEA registration and controlled substance licensing

Facts

DEA listing

DEA lists Illinois under: Second CS License Requirement

Note

DEA's page titles this column 'Second CS License Requirement', which DEA's page presents as a state controlled substance license in addition to the medical license. Confirm the exact requirement with the Illinois licensing board before prescribing.

DEA: Medical State Licensure and/or Controlled Substance Licensure

Moving to or adding Illinois

• Get the Illinois license first.
• Then apply for or update the DEA registration for Illinois. Per the DEA Registration Q&A, a separate DEA registration is needed in each state where you practice and dispense controlled substances.
• DEA registration page

NPs and PAs

DEA treats NPs and PAs as mid-level practitioners. Authority comes from state law, so check the Illinois board.

Neighbors

3 of the 5 bordering states are listed with a second-CS-license flag: Indiana, Iowa, Missouri.

• Indiana — second-CS-license flag.
• Iowa — second-CS-license flag.
• Kentucky — one-license flag.
• Missouri — second-CS-license flag.
• Wisconsin — one-license flag.

Count named qualifying land/river neighbors; exclude water-only and corner-only contacts. Neighbor status grants no practice authority.

In this state, in context

BLS OEWS May 2025 annual mean employee wages — physicians, all other: $220,020; nurse practitioners: $130,940; physician assistants: $131,880. “Physicians, all other” is a broad category, not all physicians or a specialty average. These are employee wage estimates, not total compensation or contract rates.

Illinois physicians, all other pay · Illinois nurse practitioners pay · Illinois physician assistants pay · Illinois nurse anesthetists pay

Decision checklist for Illinois

• Identify each principal place of business or professional practice in Illinois where controlled substances are dispensed.
• Read 21 CFR 1301.12 for separate registration at each such place at one general physical location.
• Confirm state authorization separately; a DEA registration depends on authority under state law.

The DEA Registration Q&A separately addresses different-state practices; confirm individual state authority.

Find your state board (FSMB directory)

Sources

• DEA: Medical State Licensure and/or Controlled Substance Licensure
• DEA Diversion Control Division: Registration Q&A
• 21 CFR 1301.12 (Cornell LII)
• DEA: Registration

General information, not legal or insurance advice. Confirm details with the state board, DEA, or the carrier.